肺癌

1. CIK cell therapy

CIK cells are the human peripheral blood mononuclear cells in vitro co-culture with a variety of cytokines following a period of a group of heterogeneous cells, because both a strong anti-tumor T-lymphocyte activity and natural killer (NK) cells, widely advantage of killing tumor spectrum, is considered a new generation of tumor cells in adoptive immunotherapy of the preferred solution. Conventional procedures are as follows: cell collection → in vitro induced differentiation of whole quality control → → Determination of biological activity → → CIK cell transfusion follow-up. From each treatment (cells collected from the end of reinfusion) a total of 10-14 days, each course reinfusion two times (two consecutive days). In 2000, the Center launched a CIK cell therapy, involving cancer, including lymphoma, kidney cancer, lung cancer, liver cancer, colorectal cancer, ovarian cancer and breast cancer, this cell therapy has a strong anti-tumor activity to stimulate the body to produce anti - tumor immune response, efficacy is very satisfied with minor side effects.

2001.01 - 2005.08 A total of 274 people received CIK cell therapy, 198 patients were male, female 76 cases, with an average age of 56.34 years. In which the digestive tract (including esophagus, stomach, intestines, pancreas) tumors of 81 cases, 54 cases of lung cancer, liver cancer, 36 cases of renal cell carcinoma 29 cases, 20 cases of breast cancer, lymphoma in 13 cases, the other 41 cases.

Receiving the treatment of patients, Ⅰ - Ⅱ patients accounted for 17.1%, Ⅲ - Ⅳ period accounted for 82.9% of patients; treatment for more than three courses of 85 cases, two courses were 48 cases, the rest is a course of treatment, number of treatment up to 34. The course of treatment, in addition to a transient fever, chills, and other adverse reactions not found outside, the overall effective rate was 35%.

2. Dendritic cells (DC) vaccines

DC is the human body the most powerful professional antigen-presenting cells, with activation of naive T-cell function. A large number vivo and in vitro experiments confirmed that the different forms of tumor antigen pulsed DC in vitro after the application, can generate strong anti-tumor immunity, and can inhibit tumor growth and metastasis. DC-based vaccine therapy in biological treatment is increasingly important. The Center since 1996, the use of tumor cell lysate, irradiated cytokine-modified tumor cells, peptides such as tumor vaccine prepared to carry out targeted lung cancer, gastrointestinal cancer, ovarian cancer, renal cancer adjuvant therapy, the results confirmed that the therapy can effectively stimulate the body to produce anti-tumor immune response, its safety and feasibility have been confirmed, the anti-tumor effects of satisfaction, can effectively prolong the survival of patients after time and improve patient quality of life.

At present, 52 patients with solid tumors after treatment of patients, patient tumor samples lysates as antigen pulsed dendritic cells, 35 cases were males and 17 females with a mean age of 54.7 years. In which 18 cases of lung cancer, digestive tract (including esophagus, stomach, intestines, pancreas) tumors 12 cases, nine cases of kidney cancer, liver cancer, 4 cases, 4 cases of melanoma, lymphoma, 4 cases, other 1 case. Receiving the treatment of patients, Ⅰ - Ⅱ patients accounted for 69.2%, Ⅲ patients with 30.8%; treatment for more than three courses of 48 cases, number of treatment up to 14 times. The course of treatment, in addition to a transient fever, chills, not found outside the obvious side effects.

3. GM-CSF-modified tumor vaccine

GM-CSF is a strong incentive for macrophages and dendritic cells and other antigen-presenting cell proliferation, differentiation, activation, maturation and chemotactic cytokines. This treatment method uses a complete "tumor cell", to provide full, including known and unknown patient's tumor antigens match, can induce a strong anti-tumor-specific immune response. This treatment is the general process is as follows: The operation to collect tumor samples → → → vaccine, intradermal / subcutaneous injection → clinical efficacy and immune response monitoring, injection time interval of 1 week; were injected six times. At home and abroad have been applied to a variety of tumors including: prostate cancer, non-small cell lung cancer, ovarian cancer, pancreatic cancer, kidney cancer, multiple myeloma, acute myeloid leukemia. Branch Application of biological treatment GM-CSF-modified tumor vaccine technology in the treatment of lung, colon, renal cell carcinoma and melanoma and other progress has been made.

Undergraduate Room with GM-CSF vaccine treatment of dozens of cancer patients showed a significant anti-tumor effect, can effectively prolong the postoperative survival time of patients and improve quality of life. In which the vaccine with GM-CSF treated nine patients with metastatic lung cancer, of which 4 cases of female patients, 5 cases of male patients, with an average age of 57.5 years. 5 patients DTH positive (positive rate 55.6%). Follow-up after treatment 4-6 times found in 7 SD (Disease stabilisation), 1 person PD (progression stabilisation), 1 died.

4. Kinship between haploidentical allogeneic hematopoietic stem cell and individual biological treatment of basic and clinical research

Allogeneic hematopoietic stem cell transplantation can take advantage of GVT (graft-versus-tumor) effects to achieve solid tumor resistance to chemotherapy and anti-inhibition significantly reduces transplant-related morbidity and mortality. Undergraduate rooms currently using the activation haploidentical peripheral blood stem cell immunotherapy treatments last 100 cases of advanced or metastatic chemotherapy-resistant solid tumors, including lung, kidney, ovarian cancer and high-risk breast cancer, clinical trials have shown strong anti - tumor activity, stimulate the body to produce an effective anti-tumor effects, clinical results satisfactory.

Bio-treatment center since its inception, focusing on clinical and research work in complementary, national and provincial level has undertaken a number of research projects, a number of provincial and ministerial level scientific research achievement awards, dozens of papers published in the journal at home and abroad to participate in ed and compile monographs and more than translation. Shuo jobs every year, dozens of doctoral students, and actively carry out academic exchanges between domestic and foreign, will be advanced technologies and concepts combined with China's specific conditions to promote undergraduate academic development.