肺癌

【Product Name】 paclitaxel
Alias】 【product Taxol, purple elements, special elements
【Chemical name】 5β, 20 - epoxy -1,2 α, 4,7 β, 10β, 13α-6-hydroxy taxane -11 - ene--9 - one -4,10 - diacetate -2 - benzyl Ester -13 [(2'R, 3'S)-N-benzoyl -3 - phenylisoserine ester]
【Molecular Formula】 C47H51NO14
【Molecular Weight】 853.92
【CA S NO】 33069-62-4
Origin of the products】 【yew Taxus plants of the dry roots, leaves and bark.
Content of Taxus 【Specification】 99.5% (and Lin biological)
【】 White crystals physical properties of powder. Odorless, tasteless. Insoluble in water, soluble in chloroform, acetone and other organic solvents.
】 【Pharmacological effects of Taxol in Taxus species is a complex secondary metabolites, is currently the only kind of understanding can promote microtubule polymerization and stability of microtubules have been aggregated drug. Isotope tracer showed that only the combination of paclitaxel to the polymerization of microtubules, do not and are not aggregated tubulin dimer reaction. Cells in the cell after contact with Taxol accumulated a large number of microtubules, which interfere with microtubule accumulation of cells in various functions, in particular to enable cell division to stop at the mitotic phase, blocked the normal cell division. Through Ⅱ - Ⅲ clinical studies, paclitaxel is mainly suitable for ovarian cancer and breast cancer, lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, brain tumors also have some effects.
Taxol is a Taxus species in a complex secondary metabolites, is currently the only kind of understanding can promote microtubule polymerization and stability of microtubules have been aggregated drug. Isotope tracer showed that only the combination of paclitaxel to the polymerization of microtubules, do not and are not aggregated tubulin dimer reaction. Cells in the cell after contact with Taxol accumulated a large number of microtubules, which interfere with microtubule accumulation of cells in various functions, in particular to enable cell division to stop at the mitotic phase, blocked the normal cell division.
History】 【found
Vanni 1963, the U.S. chemist (MC Wani) and Wall (Monre E. Wall) for the first time from one grows in the forests of the western United States the title Pacific Grand Fir (Pacific Yew) isolated bark and wood to crude Taxol material. In screening experiments, Wani and Wall found that crude extracts of taxol in vitro culture of mouse tumor cells have high activity, and begin to separate the active ingredients. Because the active ingredients in plants were very low until 1971 that they did with the Duke (Duke) professor of chemistry at the University of Lemke Jaafar (Andre T. McPhail), and through x-ray analysis identified the active ingredient in chemical structure - a tetracyclic diterpenoid compounds, and it named paclitaxel (taxol).