肺癌

【Usage consumption】
General clinical use of Taxol procedures are as follows:
1. First ask whether the patient allergic history, and view the white blood cell and platelet data. There is a history of allergy and leukocyte / thrombocytopenia should be used with caution.
2. Since this drug can cause allergic reactions, in the administration of 12 hours and 6 hours ago taking dexamethasone 20mg, administered the first 30 ~ 60 minutes to give oral diphenhydramine 50mg and cimetidine 300mg intravenous injection.
3. Commonly used dose of paclitaxel 135 ~ 175mg/m2, should be first injection and in normal saline or 5% glucose solution 500 ~ 1000ml, the need to use glass bottles or polyethylene infusion set, the application specially designed hose and 0.22μm The microporous membrane filtration.
4. Infusion should be every 15 minutes after the start of blood pressure, heart rate, breathing time, watch for allergic reactions.
5. The general infusion of 3 hours.
6. After the injection of blood should be checked every week, as at least 2 times, 3 to 4 weeks, as the case may be repeated.
It can be used with cisplatin, carboplatin, ifosfamide, fluorouracil, doxorubicin, VP-16 and other joint applications, such as low blood when applied G-CSF, or paclitaxel plus G-CSF prophylaxis.
【Note】
1. Hematologic toxicity: In order to limit dose to improve the main factors, generally less than 1500/mm3 in the white blood cells should be auxiliary applications G-CSF, platelets less than 30,000 / mm3 of blood components should be lost.
2. Allergic reactions: In addition to pre-processing, if, only slight symptoms such as facial flushing, skin reactions, heart rate slightly faster, blood pressure, easing withdrawal can not can be Disu slow. However, if severe reactions such as blood pressure is low, angioedema, difficulty breathing, body find measles, should be discontinued and to give appropriate treatment. Patients with severe allergies should not be re-applied the next Taxol treatment.
3. Nervous system: The most common of Zhizhi numb. About 4% of patients, particularly noticeable when high doses of sensory and motor impairment and reduced tendon reflexes. There have been isolated reports infusion grand mal epilepsy.
4. Cardiovascular: a transient tachycardia and hypotension more common, generally did not require treatment. However, in the first hour of infusion should be closely observed, after addition of patients with severe conduction block do not have to observe the first hour.
5. Joints and muscles: about half of the patients in 2 ~ 3 days after treatment will feel joint and muscle pain, with the dose-related. Usually resume within days. Given G-CSF in patients with muscle pain will increase.
6. Hepatobiliary system: Because taxol most excreted from the bile of patients with hepatobiliary disease should be carefully observed. The information in thousands of cases of about 8% of patients had elevated bilirubin, 23% of patients with elevated alkaline phosphatase, 18% had elevated aspartate transaminase. However, paclitaxel is currently no information on the serious damage to the liver.
7. Other: gastrointestinal reactions although uncommon but is generally not heavy, a few may have diarrhea, and mucositis. Mild hair loss are more common.